Newborn Screening Tests Save Lives, Facilitate Treatment

Pediatrician Talks About Screenings Done Before Infants Leave the Hospital

A lot happens before a newborn baby leaves the hospital, but perhaps most important is the tiny “heel stick” to draw a tiny amount of blood. This small sample is then sent to state laboratories to test for a wide range of disorders.

Courtney LaCaze-Adams, M.D., a Washington Township Medical Foundation pediatrician, is hoping to encourage pregnant families with a newborn to learn more about this screening, which can save lives.

“Newborn screening is one of the first and largest of the population-based screening programs we have in the United States,” explains Dr. LaCaze-Adams. “Millions of infants are screened every year for diseases that would otherwise cause significant morbidity and mortality, and because of these screenings we see between 3,000 to 5,000 diseases that wouldn’t be picked up until much later.”

A good example of diseases that are now routinely tested for, she says, are thyroid disorders. The thyroid gland makes thyroid hormones that are necessary for normal brain growth and development. Notably, according to Dr. Lacaze-Adams, the most critical period for the effect of thyroid hormone on brain development is in the first few months of life.

“In the case of congenital hypothyroidism, there is virtually a 100 percent chance of the infant developing mental retardation if the disease is not detected and treatment is not started early enough,” she says. “Prior to newborn screening, it was one of the most prevalent causes of mental retardation. Now, due to newborn screening, it is the most preventable cause of mental retardation in the developed world.

This is one example of why she calls newborn screening “a pretty amazing program.” and click on “Find My Physician.” For more information about newborn screenings, visit the California Department of Public Health’s Web site, and search for the Newborn Screening Program. Washington Hospital also offers a variety of prenatal and parenting classes. Visit to see the class calendar.

“What happens is when a baby is greater than a day old, he or she will get a little stick on the heel to take some blood, which is sent to the state where they run the tests,” she explains. “If the results are abnormal, primary care physicians get the results back within a week. This means we can start treatment right away for these infants.”

“If we get a positive diagnosis of congenital hypothyroidism, we will repeat the test, but we also will begin treatment right then with thyroid medication. In these cases, morbidity improves dramatically, which means these infants usually go on to develop normal intelligence and grow and develop normally in all respects. Newborn screening for this disease has completely has changed these families and infants’ lives.”

Dr. LaCaze-Adams is passionate about informing parents about newborn screenings and says the history of newborn screening really underscores the importance of these tests.

“Newborn screening was started by a gentleman whose child was mentally impaired,” she relates. “He was a scientist and did a lot of research looking into what causes mental retardation and he found out that his daughter had a defect in her ability to properly break down an amino acid called phenylalanine. The disease, now called Phenylketonuria (PKU), causes mental retardation by an abnormal buildup of amino acids that damages the developing brain.

“Due to his research, the PKU test was added to the newborn screen in the 1960s, and now, when we give these infants a proper diet—low in phenylalanine—they do not develop mental retardation.”

Since this advancement, according to Dr. LaCaze-Adams, the number of disorders—many of which can be treated or reversed—currently screened for has grown exponentially.

An example of one of the diseases now screened for is cystic fibrosis (CF). According to the Cystic Fibrosis Foundation, approximately 30,000 children and adults in the United States have cystic fibrosis and an additional 10 million more—or about one in every 31 Americans—are carriers of the defective CF gene, but do not have the disease.

“Cystic fibrosis, which is a common genetic disease detected through newborn screening, wasn’t being diagnosed until early childhood just five years ago,” she says. “Now diagnosis is within a one-month timeline since the addition of CF on the newborn screen in 2007.”

Dr. LaCaze-Adams cautions that there are instances of false positive results that must be re-tested and she understands that the process is frightening for parents. However, she says the benefits far outweigh the fear and uncertainty.

“You have to think of all the thousands of infants that we’re screening, and all those that have real illnesses whose lives we’re now able to improve,” she says. “Say a disease doesn’t have a specific cure, like cystic fibrosis. Even in these cases, there are important treatments and therapies that can help the child’s symptoms and progression of disease. There’s so much we can offer patients and their families in terms of treatment centers, support groups, and early intervention services.”

Dr. LaCaze-Adams encourages families to learn more about newborn screening and the positive impact it has—and will continue to have—on families. She also points out that each state has different list of diseases that it screens for and that California has some of the broadest screenings categories.


(Courtesy: Washington Hospital Healthcare System, Original Article at

This entry was posted in CAH, Congenital Hypothyroidism, Dried Blood Spot, Genetic Disorders, IEM, IMD, Inborn Errors of Metabolism, inborn metabolic syndrome, Infant, Infant Mortality rate, Metabolic Disorders, Neonatal Screening, Newborn, Newborn Screening, Newborns and tagged , , , , , , , , , , , , , , . Bookmark the permalink.

1,272 Responses to Newborn Screening Tests Save Lives, Facilitate Treatment

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    As a father I think in India Newborn screening is more useful and necessary because if we pick a disorder early, we can save many lives and the baby can lead a normal life. NBS test is very sensitive and helps in a timely diagnosis and treatment. Now, the goal is to unite policy makers, doctors, and laboratories so that the test and treatment is easily available to all newborn babies.

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      To obtain the free app Star Poker India by Manjunath Kulkarni, get iTunes now. Located close to the Ulsoor Lake it hosts numerous poker tourneys and occasions from 1 PM throughout the whole night time till 7AM. The game of poker is globally recognised to be a game which requires a high level of intellect and psychological prowess. When you wish to study and grasp online poker game then you possibly can choose to play free online poker and enjoy the recreation in the best possible method. However, some Indian States expressly prohibit any type of on-line gaming and gambling of their jurisdictions.

      As soon as a desk is mastered, poker recreation gamers can rapidly fold over and move their stakes to a different ready table. A solution to this could be to have your bank account abroad (significantly if you are travelling) and to use Indian ATMs to withdraw funds from this account from while in India. OTP affirmation and different safety measures are taken to be able to provide maximum protection for our players. Indian gamers are logging onto the web and try their luck by taking part in varied poker tournaments and taking part in actual cash on-line poker money games. Has world-class poker software to make your poker sport enjoying expertise a unbelievable one.

      Most poker video games are performed in dollars or euros and India has quite strict forex management legal guidelines that make it difficult to change larger quantities of forex without specific licenses. At current land-based gambling is only authorized in three states – Goa, Daman, and Sikkim. Any sport/sport that provides thrill and excitement is price investing time on. You’ll see quite a bit changing and loads happening round poker in India very quickly. Rajeev Raut who has performed poker around the world since 1997 carried ahead his passion for the sport by opening this poker site in Silicon Valley of India. Since then, there have been a number of Indian court docket rulings pertaining to the standing of poker.

      Earlier many poker players from India had no possibility other than to take part in International poker tournaments in numerous countries where they might or might not get a chance to make it large. Ltd was given the first online poker license and the corporate which runs the web poker website will broaden its choices in Nagaland. To be on a safer aspect, it’s greater to adjust to numerous techno approved legal guidelines of India whereas opening an online based mostly playing, gaming and betting platform reasonably than dealing with the punitive provisions of Indian legal guidelines. The Indian gambling market is estimated to be value US$60 billion per 12 months, of which about half is illegally guess.

      As we’ve seen, they’ve already formed a partnership with Adda52, and it would not be a surprise to see India locations on the tour in future. To continue, a number of payment aggregators or processors, within the framework of the RBI (Reserve Bank of India) are offering deposit and withdrawal facilities for playing on-line rummy and online poker in India. Frequent freeroll tournaments are also on accessible, permitting you to enter without cost with the possibility to win big. In addition to Karnataka, West Bengal and Nagaland, the Gujarat Excessive Court has asked the state government to clarify its stance on poker and the Kerala government is considering if the sport will be categorised as a one in all ability.

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      Essel Group is also the official distributor of lotteries organised by some state
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      Players who wish to lengthen their accomodation for PLO occasion, can achieve this with extra cost of 2,500 per night/individual.
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      The primary online gaming license (paywall) awarded in India was issued by the
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      It has attracted the youths from India and foreigner vacationers loads in current time.
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